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Examining Fatal Opioid Overdoses in Marion County, Indiana

机译:在印第安纳州马里恩县检查致命的阿片类药物过量

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摘要

Drug-related overdoses are now the leading injury-related death in the USA, and many of these deaths are associated with illicit opioids and prescription opiate pain medication. This study uses multiple sources of data to examine accidental opioid overdoses across 6 years, 2010 through 2015, in Marion County, IN, an urban jurisdiction in the USA. The primary sources of data are toxicology reports from the county coroner, which reveal that during this period, the most commonly detected opioid substance was heroin. During the study period, 918 deaths involved heroin, and there were significant increases in accidental overdose deaths involving both heroin and fentanyl. In order to disentangle the nature and source of opioid overdose deaths, we also examine data from Indiana’s prescription drug monitoring program and the law enforcement forensic services agency. Results suggest that there have been decreases in the number of opiate prescriptions dispensed and increases in law enforcement detection of both heroin and fentanyl. Consistent with recent literature, we suggest that increased regulation of prescription opiates reduced the likelihood of overdoses from these substances, but might have also had an iatrogenic effect of increasing deaths from heroin and fentanyl. We discuss several policy implications and recommendations for Indiana.
机译:在美国,与药物有关的药物过量现在是与伤害有关的主要死亡,其中许多死亡与非法阿片类药物和处方鸦片止痛药有关。这项研究使用多种数据来源研究了2010年至2015年这6年间在美国城市辖区马里恩县的意外阿片类药物过量。数据的主要来源是县验尸官的毒理学报告,该报告显示,在此期间,最常见的阿片类物质是海洛因。在研究期间,有918例海洛因死亡,而涉及海洛因和芬太尼的药物过量意外死亡显着增加。为了弄清阿片类药物过量死亡的性质和来源,我们还检查了印第安纳州处方药监测计划和执法法证服务机构的数据。结果表明,配发的鸦片处方数量减少了,海洛因和芬太尼的执法检测也有所增加。与最新文献一致,我们建议加强对处方鸦片制剂的管制可降低这些物质过量服用的可能性,但也可能具有增加海洛因和芬太尼死亡人数的医源性作用。我们讨论了印第安纳州的一些政策含义和建议。

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